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Andrea Mazza, Maria Grazia Bendini, Massimo Leggio, Umberto Riva, Carmine Ciardiello, Sergio Valsecchi, Raffaele De Cristofaro, Giampiero Giordano
DOI: http://dx.doi.org/10.1093/europace/eut389 617-618 First published online: 21 February 2014

We appreciate the letter by Márguez and colleagues and we are thankful for their valuable comments to our paper.1 Recent guidelines2 recommend cardiac resynchronization therapy (CRT) in heart failure (HF) patients with reduced left ventricular ejection fraction (LVEF) and expected high percentage of ventricular pacing, to decrease the risk of worsening HF. Nonetheless, as correctly noticed by DeSisti et al.3 in their previous work, an LVEF cut-off value has not yet been defined. They also noticed that chronic right ventricular pacing can induce a reduction in LVEF of 5–10% points, and therefore suggested an LVEF cut-off value of 40–45% as criterion for …

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