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Europace Advance Access published online on October 9, 2008
Europace, doi:10.1093/europace/eun271
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

REVIEW

Targeting calcium handling in arrhythmias

Gudrun Antoons and Karin R. Sipido*

Division of Experimental Cardiology, Department of Cardiovascular Medicine, University of Leuven, KUL, Campus Gasthuisberg O/N 7th Floor, Herestraat 49, B-3000 Leuven, Belgium

Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering abnormal depolarizations and indirectly by modulating action potential time course and duration. Recent data have shown the importance of these mechanisms in rare genetic diseases but also in more common conditions such as heart failure. Modulating Ca release from the sarcoplasmic reticulum via the ryanodine receptor, Ca uptake via sarcoplasmic reticulum Ca ATPase or Ca removal from the cell via the Na/Ca exchanger, are potential approaches to reduce arrhythmias. New tools allow exploring these ideas. The principles underlying this approach and the first results are critically reviewed.

Key Words: Calcium, Cardiac myocyte, Sarcoplasmic reticulum, Na/Ca exchange, Arrhythmias, Ryanodine receptor, SERCA

* Corresponding author. Tel: +32 16 347153; fax: +32 16 345844. E-mail address: karin.sipido{at}med.kuleuven.be

Manuscript submitted 30 June 2008. Accepted after revision 8 September 2008.


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