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Europace Advance Access published online on October 11, 2007
Europace, doi:10.1093/europace/eum225
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Left ventricular pacing by automatic capture verification

Mauro Biffi*, Matteo Bertini, Matteo Ziacchi and Boriani Giuseppe

Institute of Cardiology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy

Aims: To investigate the feasibility of transvenous left ventricular (LV) pacing by autocapture at long term. A reliable measurement of LV evoked response (ER) is the pivotal requirement for beat-to-beat detection of ventricular capture and automatic output adjustment.

Methods and results: Seven patients with accepted class I indication to permanent cardiac pacing received a DDDR pacemaker with automatic output adjustment based on beat-to-beat capture verification (Insignia Ultra 1290, Guidant), whose ventricular port was connected to a LV lead placed in a branch of the coronary sinus. The device allows LV threshold trending, performing a threshold test every 21 h, and diagnoses acute and non-acute issues of ER detection during follow up. Average follow up after implantation was 34 ± 6 months (range 28–45, median 34). Left ventricular pacing threshold showed an increase from implantation (1.2 ± 0.4 V at 0.4 ms) that peaked at week 4 (1.6 ± 0.7 V at 0.4 ms), and returned to baseline (1.1 ± 0.5 at 0.4 ms) by the end of the 7th week. Autocapture performance at long term, as assessed by the trend of LV threshold and of ER diagnostic issues, did not show any pitfall.

Conclusions: Our observations support the feasibility and safety of capture verification during LV pacing alone. A possible application of this pacing technology could be biventricular stimulation.

Key Words: Left ventricular pacing, Automatic capture verification, Pacing threshold, Evoked response

* Corresponding author. Tel: +39 051 345898; fax: +39 051 344859.E-mail address: mauro.biffi{at}aosp.bo.it, mbiffi{at}aosp.bo.it

Manuscript submitted 7 May 2007. Accepted after revision 18 September 2007.


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