Europace Advance Access published online on October 11, 2007
Europace, doi:10.1093/europace/eum221
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Prevalence of Brugada sign in a Greek tertiary hospital population
Second Department of Cardiology, Evangelismos General Hospital of Athens, 45-47 Ipsilantou St., 10676 Athens, Greece
Aims: The purpose of the present study was to determine for the first time the prevalence of Brugada-type electrocardiographic (ECG) pattern (Brugada sign) in unselected individuals served by an urban Greek tertiary hospital during a 4-year time period.
Methods and results: Among 11 488 individuals (6640 males, 4848 females), 25 (23 males, 2 females, aged 36.8 ± 19.2 years) were found to display the Brugada sign (0.22%). Two cases exhibited the diagnostic type 1 ECG pattern (0.02%) and 23 subjects fulfilled the ECG criteria for type 2 or 3 patterns (0.2%). The incidence of Brugada sign was higher among men (0.34%) than in women (0.04%). Structural heart disease was established in four cases (one of them exhibiting a type 1 ECG pattern). Twenty-one individuals (19 males, 2 females, aged 29.7 ± 10.7 years) without structural heart disease displaying Brugada-type ECG features (4 cases with spontaneous or procainamide-induced type 1 ECG pattern) were subsequently selected and closely followed up for 24 ± 12 months. No mortality or life-threatening ventricular arrhythmias were recorded during this period.
Conclusion: The Brugada-type ECG pattern is infrequently seen in a Greek hospital-based population. All subjects with Brugada sign and structurally normal hearts displayed a benign clinical course without arrhythmic events during a relatively long follow-up period.
Key Words: Brugada syndrome, Prevalence, Prognosis, Sudden cardiac death
* Corresponding author: Tel: +30 210 6843854; fax: +30 210 7217687. E-mail address: k.letsas{at}mail.gr
Manuscript submitted 3 June 2007. Accepted after revision 9 July 2007.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Veltmann, C. Wolpert, F. Sacher, P. Mabo, R. Schimpf, F. Streitner, J. Brade, F. Kyndt, J. Kuschyk, H. Le Marec, et al. Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges Europace, October 1, 2009; 11(10): 1345 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Sinner, A. Pfeufer, S. Perz, E. Schulze-Bahr, G. Monnig, L. Eckardt, B.-M. Beckmann, H.-E. Wichmann, G. Breithardt, G. Steinbeck, et al. Spontaneous Brugada electrocardiogram patterns are rare in the German general population: results from the KORA study Europace, October 1, 2009; 11(10): 1338 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Probst and H. Le Marec Brugada syndrome: where are you? Europace, October 1, 2009; 11(10): 1260 - 1261. [Full Text] [PDF]
|
|
|
|
|
|
C. Veltmann, C. Wolpert, R. Schimpf, P. Mabo, H. LeMarec, M. Borggrefe, and V. Probst The ajmaline challenge and a strange ECG: reply Europace, October 1, 2009; 11(10): 1406 - 1407. [Full Text] [PDF]
|
|
|
|
|
|
N. P. Sidik, C. N. Quay, F. C. Loh, and L. Y. Chen Prevalence of Brugada sign and syndrome in patients presenting with arrhythmic symptoms at a Heart Rhythm Clinic in Singapore Europace, May 1, 2009; 11(5): 650 - 656. [Abstract] [Full Text] [PDF]
|
|