Skip Navigation



Europace Advance Access published online on July 18, 2007
Europace, doi:10.1093/europace/eum143
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
9/9/732    most recent
eum143v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Achilli, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Achilli, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Efficacy of cardiac resynchronization therapy in very old patients: the Insync/Insync ICD Italian Registry

Augusto Achilli1,*, Federico Turreni1, Maurizio Gasparini2, Maurizio Lunati3, Massimo Sassara1, Massimo Santini4, Maurizio Landolina5, Luigi Padeletti6, Andrea Puglisi7, Mario Bocchiardo8, Serafino Orazi9, Giovanni Battista Perego10, Sergio Valsecchi11, Alessandra Denaro on behalf of the InSync/InSync ICD Italian Registry Investigators11

1 Belcolle Hospital, Via Monfalcone 20/A, 01100 Viterbo, Italy; 2 IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy; 3 Niguarda Hospital, Milan, Italy; 4 S. Filippo Neri Hospital, Rome, Italy; 5 Policlinico S. Matteo IRCCS, Pavia, Italy; 6 Careggi Hospital, Firenze, Italy; 7 Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy; 8 Civile Hospital, Asti, Italy; 9 S. Camillo Hospital, Rieti, Italy; 10 Istituto Auxologico S. Luca Hospital, Milano, Italy; 11 Medtronic Italia, Rome, Italy

Aims To assess the effects of cardiac resynchronization therapy (CRT) in ≥80-year-old patients vs. patients <80 years, in terms of clinical, functional, and echocardiographic parameters after 12 month of CRT, survival, and incidence of arrhythmic events.

Methods and results The study population consisted of 1181 CRT patients (85 were ≥80 years old). They were enrolled in a national observational registry and underwent baseline evaluation and periodical follow-up visits. In the overall population, New York Heart Association class and ejection fraction (EF) improved and ventricular diameters decreased. Similar changes were observed in the two groups. In the study population, 157 patients died, 144 (13%) in the <80 years group and 13 (15%) in the ≥80 years group. There was a higher all-cause mortality (log-rank test, P = 0.015) among ≥80 years patients, with a trend towards higher sudden cardiac death (SCD) (P = 0.057), but similar non-SCD (P = 0.293). Using the combined endpoint of SCD or appropriate shock from a defibrillator for ventricular fibrillation, no significant differences resulted between groups (P = 0.455). In both groups, lower EF was associated with higher mortality.

Conclusion Cardiac resynchronization therapy demonstrated similar efficacy in patients aged ≥80 years and in those under 80, in terms of clinical and functional parameters and reverse remodelling. Similarly, CRT resulted in comparable effects on death for heart failure and on SCD.

Key Words: Cardiac resynchronization therapy, Heart failure, Elderly

* Corresponding author. Tel: +39 0761 339451; fax: +39 0761 339278. E-mail address: a_achilli{at}virgilio.it

Manuscript submitted 1 March 2007. Accepted after revision 21 June 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EuropaceHome page
P. W.X. Foley, S. Chalil, K. Khadjooi, R. E.A. Smith, M. P. Frenneaux, and F. Leyva
Long-term effects of cardiac resynchronization therapy in octogenarians: a comparative study with a younger population
Europace, November 1, 2008; 10(11): 1302 - 1307.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.