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Europace Advance Access published online on May 31, 2007
Europace, doi:10.1093/europace/eum110
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Clinical predictors of atrial fibrillation in Brugada syndrome

Mohamad Ali Babai Bigi, Amir Aslani* and Shahab Shahrzad

Cardiology Department, Namazee Hospital, Shiraz University of Medical Sciences, Zand Avenue, PO Box 71935-1334, Shiraz, Iran

Aims Atrial arrhythmias have been reported in patients with Brugada syndrome. The aim of this study was to evaluate clinical predictors of atrial fibrillation (AF) in Brugada syndrome.

Methods and results Patients diagnosed with Brugada ECG pattern were enrolled in the study. Type 1, 2, and 3 Brugada ECG pattern was found in 28, 56, and 31 patients, respectively. A total of 85 healthy age and gender-matched subjects were selected as a control group. Mean age, maximum P-wave duration (Pmax), P-wave dispersion (Pdisp), and left atrial dimension were not significantly different between patients and controls. There were no differences between Pmax, Pdisp, and left atrial dimension of the type 1, 2, and 3 Brugada patients. Spontaneous paroxysmal AF was detected in 15 of 28 type 1 Brugada patients (53%) and none of the type 2 and 3 Brugada patients. All 15 patients with AF had at least one episode of paroxysmal AF and none of the patients showed persistent or chronic AF. All 15 patients who had paroxysmal AF had previous life threatening cardiac events. In contrast, paroxysmal AF did not occur in type 1 Brugada patients without previous life threatening cardiac events. In multiple regression analysis, only the occurrence of previous life threatening cardiac events was a risk factor for paroxysmal AF (P = 0.0001).

Conclusion It is concluded that the most important predictor of AF in Brugada syndrome is the occurrence of previous life threatening cardiac events.

Key Words: Atrial fibrillation, Brugada syndrome, Ventricular fibrillation

* Corresponding author. Tel: +98 711 2277181; fax: +98 711 2277182. E-mail address: draslani{at}yahoo.com

Manuscript submitted 9 March 2007. Accepted after revision 27 April 2007.


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