Europace Advance Access published online on April 17, 2007
Europace, doi:10.1093/europace/eum035
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Reduction of ventricular tachyarrhythmia by treatment of atrial fibrillation in ICD patients with dual-chamber implantable cardioverter/defibrillators capable of atrial therapy delivery: the REVERT-AF Study
1 Department of Cardiology and Angiology, University Hospital Münster, D-48129 Münster, Germany; 2 Heart Center, Ludwigshafen, Germany; 3 Department of Cardiology and Angiology, Hannover Medical School, Germany; 4 Department of Cardiology, University Hospital Mainz, Germany; 5 University Heart Center Essen, Germany; 6 University Heart Center Hamburg, Germany; 7 Department of Cardiology, University Hospital Würzburg, Germany; 8 Institute of Medical Informatics and Biomathematics Münster, Germany; 9 First Department of Medicine—Cardiology, University Hospital Mannheim, Germany
Aims The purpose of this prospective, randomized, multicentre study was to investigate whether the incidence of ventricular tachyarrhythmia can be reduced in standard implantable cardioverter/defibrillator (ICD) patients by implanting a dual-chamber ICD capable of atrial therapy delivery.
Methods and results A Jewel AF or GEM III AT ICD (Medtronic Inc., Minneapolis, MN, USA) was implanted in 122 patients (62.3 ± 10.5 years; 84.4% male; coronary artery disease 71.3%; left ventricular ejection fraction 39.7 ± 13.6%; secondary ICD indication 91%). Overall, 31.2% of the patients had paroxysmal atrial fibrillation (AF)/atrial tachycardia (AT) before ICD implantation (n = 38). Implantable cardioverter/defibrillator therapies for AT/AF were activated and de-activated every 3 months in a cross-over study design. The mean follow-up was 18.5 ± 7.7 months (6.29 ± 2.2 cross-over/patient). Overall, there were 684 episodes of ventricular tachyarrhythmias in 48.4% of patients (n = 59). In 33.6% of patients (n = 41), 532 supraventricular tachyarrhythmias occurred. Activation of ICD therapies for AT/AF did not result in a reduction of ventricular tachyarrhythmias (P = 0.92). Patients with monomorphic ventricular tachycardias (mVTs) as index arrhythmia for ICD implantation or inducible mVTs in the electrophysiological study had the highest probability of recurrences of ventricular tachyarrhythmias.
Conclusion For patients with standard indications for ICD therapy and no indication for cardiac pacing, a dual-chamber ICD capable of atrial tachyarrhythmia treatment offers no benefit concerning a reduction of ventricular tachyarrhythmias.
Key Words: Implantable cardioverter/defibrillator, Capability of atrial therapy, Recurrence rate of ventricular tachyarrhythmia
* Corresponding author. Tel: +49 251 8347683; fax: +49 251 8347864. E-mail address: gradaus{at}uni-muenster.de
Manuscript submitted 4 January 2007. Accepted after revision 14 February 2007.
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