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Europace 2007 9(1):50-54; doi:10.1093/europace/eul137
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

CRT

Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

Houman Ashrafian*, Mark J. Mason and Andrew G. Mitchell

Department of Cardiology, The Royal Brompton and Harefield NHS Trust, Harefield Hospital, Middlesex UB9 6JH, UK

The evolution of hypertrophic cardiomyopathy (HCM) towards dilatation and hypokinesis is an increasingly recognized complication with a high incidence of adverse outcomes, including sudden cardiac death, requiring defibrillator implantation and cardiac transplantation. It is generally regarded as the irreversible ‘burnt-out’ end-stage manifestation of HCM. We report one of the first cases of profound regression of the dilated-hypokinetic state by the application of biventricular pacing and cardiac resynchronization therapy (CRT). Reviewing the literature on the role of pacing in HCM and the energetic rationale for CRT in HCM prompts us to suggest that further systematic studies are needed urgently to assess the role of CRT in HCM variants.

Key Words: Dilated-hypokinetic, Hypertrophic cardiomyopathy, Cardiac resynchronization therapy, Biventricular pacing

* Corresponding author: Tel: +44 77 89 77 8075; fax: +44 18 95 82 8277. E-mail address: ashrafian{at}hotmail.com


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D. P.S. Rogers, S. Marazia, A. W. Chow, P. D. Lambiase, M. D. Lowe, M. Frenneaux, W. J. McKenna, and P. M. Elliott
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[Abstract] [Full Text] [PDF]


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