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Europace 2003 5(4):429-431; doi:10.1016/S1099-5129(03)00080-1
© 2003 by European Society of Cardiology
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SHORT SERIES REPORT

Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors

P. Bordier1, S. Garrigue1, S. S. Barold2, N. Bressolles1, S. Lanusse1 and J. Clémenty1

1Hôpital Cardiologique du Haut-Lévêque, University of Bordeaux Pessac, France; 2Florida Cardiovascular Institute and Tampa General Hospital Tampa, FL, USA

Abstract

We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil). Bradyarrhythmia was documented in two patients, considered probable in one, and was presumed related to the cholinergic therapy. Pacemaker implantation seemed justified rather than donepezil cessation. Moreover, it permitted an increase in donepezil dosage.

Key Words: Alzheimer's disease, cholinesterase inhibitors, bradycardia

Correspondence: Philippe Bordier, MD, Hôpital Cardiologique du Haut-Lévêque, Avenue de Magellan, 33604 Pessac cedex, France. Tel.: +33-5-56-76-57-82; Fax: +33-5-56-04-38-49. E-mail: phibordier{at}aol.com


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