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Europace Advance Access originally published online on October 24, 2008
Europace 2009 11(1):80-85; doi:10.1093/europace/eun288
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Pacing and Cardiac Resynchronization Therapy

Relationship between New York Heart Association class change and ventricular tachyarrhythmia occurrence in patients treated with cardiac resynchronization plus defibrillator

Antoine Lepillier1,2,*, Olivier Piot1, Bart Gerritse3, Xavier Copie1, Thomas Lavergne2, Olivier Paziaud1, Gilles Lascault1, Xavier Waintraub2, Akli Otmani2 and Jean-Yves Le Heuzey2

1 Centre Cardiologique du Nord, 26 rue des Moulins Gémeaux 93200 Saint-Denis, France; 2 Service de cardiologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc 75015 Paris, France; 3 Medtronic Bakken Research Center, Maastricht, Netherlands

Aims: In patients with advanced heart failure (HF) and prolonged QRS interval, cardiac resynchronization therapy (CRT) reduces symptoms and risk of death. The added benefit of an implantable cardioverter defibrillator (ICD) remains questionable in some patients.

Methods and results: In 332 HF patients treated with CRT-D (CRT with ICD) [65 ± 10 years, 86% men, 23% New York Heart Association (NYHA) class II, 65% class III, and 11% class IV, 70% primary prevention, 55% ischaemic cardiomyopathy, left ventricular ejection fraction 25 ± 7.5%, and QRS width 167 ± 32 ms], we evaluated the relationship between functional status change, death at 6-month follow-up (FU), and the occurrence of ventricular tachyarrhythmia/ventricular fibrillation (VT/VF). A total of 68 patients (20.5%) experienced 1266 spontaneous episodes of VT/VF during FU. There was no difference in baseline characteristics between patients with or without VT/VF, except for ICD indication (primary or secondary prevention). Improvement in NYHA class was significantly associated with a decreased occurrence of VT/VF (P = 0.004). Sixteen patients who died had significantly more often VT/VF than the survivors (50 vs. 19%, P = 0.007).

Conclusion: Within the initial 6-month post-CRT therapy, 20% of patients received an appropriate ICD therapy. Patients improving on NYHA class (responders to CRT) have less VT/VF episodes than non-responders. Discriminant criteria for CRT response are awaited to optimize the choice of the device (CRT alone, defibrillator alone, or CRT-D).

Key Words: Defibrillator, Resynchronization, Ventricular arrhythmias

* Corresponding author. Tel: +33 1 56 09 37 32. E-mail address: alepillier{at}hotmail.com

Manuscript submitted 30 May 2008. Accepted after revision 29 October 2008.


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