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Europace 2008 10(2):238-241; doi:10.1093/europace/eum283
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions©oxfordjournals.org

MINIREVIEW

Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms

Andreas Goette1,* and Uwe Lendeckel2

1 Division of Cardiology, University Hospital Magdeburg, Leipzigerstr. 44, Magdeburg 39120, Germany; 2 Institute of Experimental Internal Medicine, University Hospital Magdeburg, Magdeburg 39120, Germany

In the recent years, a tremendous amount has been learned about the pathophysiology and molecular biology of the cardiac angiotensin II system. Interestingly, the angiotensin II appears to have several effects on cardiac electrophysiology, which have not been fully appreciated so far. Therefore, this review will highlight on the basic knowledge of signal transduction and electrophysiological effects of angiotensin II, which may have an impact on the occurrence of cardiac arrhythmia.

Key Words: Angiotensin, Arrhythmias, Fibrillation, Molecular biology, Receptors, Signal transduction

* Corresponding author. Tel: +49 391 6713225; fax: +49 391 671 3202.E-mail address: andreas.goette{at}medizin.uni-magdeburg.de

Manuscript submitted 17 October 2007. Accepted after revision 28 November 2007.


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