© 2001 by European Society of Cardiology
SYNCOPE
Psychiatric conditions in patients with recurrent unexplained syncope
Department of Cardiology, University Hospital Eppendorf Hamburg, Germany; 1Department of Psychosomatic Medicine, University Hospital Eppendorf Hamburg, Germany
Abstract
AIMS: The relationship between syncope and psychiatric disorders is little investigated. This study evaluated the prevalence of psychiatric diseases and prognostic outcome in patients with recurrent unexplained syncope.
METHODS AND RESULTS: After an inconclusive standard diagnostic work-up for syncope, including head-up tilt testing, a psychiatric evaluation was offered to 50 consecutive patients with recurrent syncope. The evaluation was accepted by 26 patients (77% females, 36±16 years) and refused by 24 (63% females, 50±19 years). A psychiatric disorder was diagnosed in 21 (81%) patients: 12 had depression, four panic attacks, two general anxiety, and three a somatization disorder. Only five patients showed normal psychosocial function. Of the patients with psychiatric disorders four accepted psychiatric care, such as psychotherapy and/or pharmacotherapy; 17 patients refused treatment. During 6 months of follow-up no patient under psychiatric care had syncope, while all patients without psycho- or pharmacotherapy had recurrent syncopal events. In these patients the median of syncopal episodes was three in a 6 months interval before and after clinical assessment. Patients who refused both psychiatric evaluation and therapy continued to experience syncope as before.
CONCLUSIONS: In patients with recurrent unexplained syncope psychiatric alteration is common. However, patients seldom accepted a psychiatric evaluation and treatment.
Key Words: Recurrent unexplained syncope, psychiatric diseases
Correspondence: Rodolfo Ventura, MD, Department of Cardiology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. E-mail: ventura{at}uke.uni-hamburg.de
References
[1] Kapoor WN. Evaluation and outcome of patients with syncope. Medicine 1990; 69: 160175.[Medline]
[2] Martin GJ, Adams SL, Martin HG, Mathews J, Zull D, Scanlon PJ. Prospective evaluation of syncope. Ann Emerg Med 1984; 13: 499504.[CrossRef][Web of Science][Medline]
[3] Day SC, Cook EF, Funkenstein H, Goldman L. Evaluation and outcome of emergency room patients with transient loss of consciousness. Am J Med 1982; 73: 1523.[CrossRef][Web of Science][Medline]
[4] Kapoor WN, Karpf M, Wieand S, Peterson JR, Levey GS. A prospective evaluation and follow-up of patients with syncope. N Engl J Med 1983; 309: 197204.[Abstract]
[5] Silverstein MD, Singer DE, Mulley AG, Thibault GE, Barnett GO. Patients with syncope admitted to intensive care units. JAMA 1982; 248: 11851189.
[6] Kapoor WN. An overview of the evaluation and management of syncope. In Grubb BP and Olshansky B (Eds.). Syncope: mechanisms and management 1998; Armonk Futura Publishing Company, Inc pp. 113.
[7] Hammill SC. Value and limitations of non-invasive assessment of syncope. Cardiol Clin 1997; 15: 195218.[Medline]
[8] Benditt DG, Ferguson DW, Grubb BP, et al. Tilt table testing for assessment syncope. J Am Coll Cardiol 1996; 28: 263275.[CrossRef][Web of Science][Medline]
[9] Kapoor WN, Smith MA, Miller NL. Upright tilt testing in evaluating syncope: A comprehensive literature review. Am J Med 1994; 97: 7888.[CrossRef][Web of Science][Medline]
[10] Linzer M, Pritchett ELC, Pontinen M, McCarthy E, Divine GW. Incremental diagnostic yield of loop electrocardiographic recorders in unexplained syncope. Am J Cardiol 1990; 66: 214219.[CrossRef][Web of Science][Medline]
[11] Zimetbaum P, Kim KY, Ho KKL, Zebede J, Josephson ME, Goldberger AL. Utility of patient-activated cardiac event recorders in general clinical practice. Am J Cardiol 1997; 79: 371372.[CrossRef][Web of Science][Medline]
[12] Krahn AD, Klein GJ, Norris C, Yee R. The etiology of syncope in patients with negative tilt table and electrophysiological testing. Circulation 1995; 92: 18191824.
[13] Krahn AD, Klein GJ, Yee R. Recurrent syncope: Experience with an implantable loop recorder. Cardiol Clin 1997; 15: 313326.[Medline]
[14] DiMarco JP. Value and limitations of electrophysical testing for syncope. Cardiol Clin 1997; 15: 219232.[Medline]
[15] Oh JH and Kapoor WN. Psychiatric illness and syncope. Cardiol Clin 1997; 15: 269275.[Medline]
[16] Kapoor WN, Fortunato M, Hanusa BH, Schullberg HC. Psychiatric illnesses in patients with syncope. Am J Med 1995; 99: 505512.[CrossRef][Web of Science][Medline]
[17] Koenig D, Linzer M, Pontinen M, Divine GW. Syncope in young adults: Evidence for a combined medical and psychiatric approach. J Intern Med 1992; 232: 169176.[Web of Science][Medline]
[18] Eagle KA, Black HR, Cook EF, Goldman L. Evaluation of prognostic classifications for patients with syncope. Am J Med 1985; 79: 455460.[CrossRef][Web of Science][Medline]
[19] Fitzpatrick AP, Theodorakis G, Vardas P, Sutton R. Methodology of head-up tilt testing in patients with unexplained syncope. J Am Coll Cardiol 1991; 17: 125130.[Abstract]
[20] Franke G. SCL-90-R: Die Symptom-Checkliste von Derogatis. Deutsche Fassung-Manual 1995; Goettingen Beltz.
[21] Linzer M, Pontinen M, Gold DT, Divine GW, Felder A, Brooks WB. Impairment of physical and psychosocial function in recurrent syncope. J Clin Epidemiol 1991; 44: 10371043.[CrossRef][Web of Science][Medline]
[22] Braehler EI and Scheer JW. Giessener Beschwerdebogen (GBB) 1995; 2nd ed Bern, Goettingen, Toronto, Seattle Hans Huber.
[23] Clement V and Loewe B. Fragebogen zum Koerperbild (FKB-20) 1996; Goettingen Hogrefe.
[24] Deutsches Institut für medizinische Dokumentation und Information (DIMDI). Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. 10. Revision 1994; Muenchen Urban & Schwarzenberg.
[25] Linzer M, Varia I, Pontinen M, Divine GW, Grubb BP, Estes III-NAM. Medically unexplained syncope: Relationship to psychiatric illness. Am J Med 1992; 92:(Suppl 1A), 18S25S.[Medline]
[26] Linzer M, Felder A, Hackel A, et al. Psychiatric syncope: A new look at an old disease. Psychosomatics 1990; 31: 181188.
[27] American Psychiatric Association; Diagnostic and Statistical Manual of Mental Disorders 1994; 4th ed Washington American Psychiatric Press.
[28] Lempert T and Bauer M. Mass fainting at rock concerts [letter]. N Engl J Med 1995; 332: 1721.
[29] Meade MA, France CR, Peterson LM. Predicting vasovagal reactions in volunteer blood donors. J Psychosom Res 1996; 40: 495501.[CrossRef][Web of Science][Medline]
[30] Steptoe A and Wardle J. Emotional fainting and psychophysiologic response to blood and injury: autonomic mechanisms and coping strategies. Psychosom Med 1988; 50: 402417.
[31] Moersch E, Kerz-Ruhling I, Drews S, et al. Psychopathology of myocardial infarct patients. Psyche-Stuttg 1980; 34: 493587.
[32] Grubb BP. Neurocardiogenic syncope. In Grubb BP and Olshansky B (Eds.). Syncope: mechanisms and management 1998; Armonk Futura Publishing Company, Inc, pp. 73106.
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
T Pezawas, G Stix, J Kastner, B Schneider, M Wolzt, and H Schmidinger Implantable loop recorder in unexplained syncope: classification, mechanism, transient loss of consciousness and role of major depressive disorder in patients with and without structural heart disease Heart, April 1, 2008; 94(4): e17 - e17. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Giada, I. Silvestri, A. Rossillo, P. G. Nicotera, G. F. Manzillo, and A. Raviele Psychiatric profile, quality of life and risk of syncopal recurrence in patients with tilt-induced vasovagal syncope Europace, January 1, 2005; 7(5): 465 - 471. [Abstract] [Full Text] [PDF] |
||||
![]() |
Fatma Neslihan Inal Emiroglu, S. Kurul, A. Akay, S. Miral, and E. Dirik Assessment of Child Neurology Outpatients With Headache, Dizziness, and Fainting - J Child Neurol, May 1, 2004; 19(5): 332 - 336. [Abstract] [PDF] |
||||
![]() |
J. E. David, S. H. Yale, and H. J. Vidaillet Hyperventilation-Induced Syncope: No Need to Panic Clin. Med. Res., April 1, 2003; 1(2): 137 - 139. [Abstract] [Full Text] [PDF] |
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||



