© 2000 by European Society of Cardiology
Exercise-induced neurocardiogenic syncope
Clinical data, pathophysiological aspects, and potential role of tilt table testing
Electrophysiology Section Division of Cardiology Department of Medicine, Medical College of Ohio Toledo, Ohio, U.S.A.
The evaluation of syncope occurring during exercise or occurring spontaneously in highly trained individuals presents a unique diagnostic challenge. It is of critical importance to exclude potential life-threatening disorders such as hypertrophic cardiomyopathy, long QT syndrome, right ventricular dysplasia, anomalous coronary artery distribution, valvular heart disease, myocarditis, or exercise-induced arrhythmia. This review is not directed towards identifying, treating, or determining athletic eligibility of individuals with such disorders. Rather, we endeavour to discuss the pathophysiology of exercise-induced neurocardiogenic syncope and to address the role of head upright tilt testing in evaluating syncope in athletic individuals in whom proper evaluation has excluded the presence of ischaemic heart disease or primary structural or electrical heart disease.
Correspondence: Blair P. Grubb, MD, Division of Cardiology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Ave., Toledo, Ohio 436145809 U.S.A.
[1] Grubb BP, Temesy-Armos P, Samoil D, Wolfe D, Hahn H, Elliot L. Tilt table testing in the evaluation and management of athletes with recurrent exercise-induced syncope. Med Sci Sports Exerc 1993; 25: 2428.
[2] Sneddon J, Scalia G, Ward D, McKenna W, Camm AJ, Frenneaux M. Exercise-induced vasodepressor syncope. Br Heart J 1994; 71: 554557.
[3] Kosinski D, Grubb BP, Kip K, Hahn H. Exercise-induced neurocardiogenic syncope. Am Heart J 1996; 132: 451452.[CrossRef][Web of Science][Medline]
[4] Sakaguchi S, Schultz J, Remole S, Adler S, Lurie K, Benditt DG. Syncope associated with exercise, a manifestation of neurally-mediated syncope. Am J Cardiol 1995; 75: 476481.[CrossRef][Web of Science][Medline]
[5] Calkins H, Seifert M, Morady F. Clinical presentation and long-term followup of athletes with exercise-induced vasodepressor syncope. Am Heart J 1995; 129: 11591164.[CrossRef][Web of Science][Medline]
[6] Maron B and Mitchell J. 26th Bethesda Conference: Recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities. J Am Coll Cardiol 1994; 24: 845899.[Medline]
[7] Mitchell JH and Wildenthal K. Static (isometric) exercise and the heart: Physiological and clinical considerations. Ann Rev Med 1974; 25: 369381.[CrossRef][Web of Science][Medline]
[8] Crawford M. Physiologic consequences of systemic training. Cardiol Clin 1992; 10: 209217.[Medline]
[9] Mitchell J, Haskell W, Raven P, Maron B, Mitchell J. Classification of sports. In: 26th Bethesda Conference: Recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities.. J Am Coll Cardiol 1994; 24: 864.[Web of Science][Medline]
[10] Mitchell J and Blomquist G. Maximal oxygen uptake. N Eng J Med 1971; 284: 1018.[Web of Science][Medline]
[11] Longhurst JC, Kelly AR, Gonyea W. Cardiovascular responses to static exercise in distance runners and weight lifters. J Appl Physiol 1980; 49: 676.
[12] Mack G, Shi H, Tripathi N, Nadel ER. Diminished baroreflex control of forearm vascular resistance in physically fit humans. J Appl Physiol 1987; 63: 105110.
[13] Mack G, Thompson C, Doerr D, Convertino V, Nadel E. Diminished baroreflex control of forearm vascular resistance following training. Med Sci Sport Exerc 1991; 23: 13671374.[Medline]
[14] Seals D and Chase P. Influence of physical training on heart rate variability and baroreflex circulatory control. J Appl Physiol 1989; 66: 18461885.
[15] Vroman N, Healy JA, Kertzer R. Cardiovascular response to lower body negative pressure following endurance training. Aviat Space Environ Med 1988; 59: 330334.[Medline]
[16] Raven P and Pawleczyk J. Chronic endurance training: A condition of inadequate blood pressure regulation and reduced tolerance to LBNP. Med Sci Sports Exer 1993; 25: 713721.[Web of Science][Medline]
[17] Kosinski D, Grubb BP, Temesy-Armos P. Pathophysiologic aspects of neurocardiogenic syncope: Current concepts and new perspectives. Pac and Clin Electrophys 1995; 18: 716724.
[18] Shalev Y, Gal R, Tchou P, Anderson A. Echocardiographic demonstration of decreased left ventricular dimensions and vigorous myocardial contraction during syncope induced by head up tilt. J Am Coll Cardiol 1991; 18: 746751.[Abstract]
[19] Ferrario G, Nicoli J, Peci P, Ginni P. Cardiac adaptation to training: Is it the key to understand the high incidence of positive tilt test in athletes? (Abstr). Pacing and Electrophys 1996; 19: 578.
[20] Ebert TJ and Denahan T. Hemodynamic responses of high fit runners during head up tilt testing to syncope. (Abstr). Proceeding of American Autonomic Society, Nashville, Tenn 1993; 11:.
[21] Stegman J, Framing H, Schiereling M. Der einflubeiner 6 Stundigen Immersion in thermo indifferentem wasser auf die regulation des kreislaufs and der leistuncsfahig keit bei trainlerten an untrainlerten. Pflugers arch ges. Physiology 1969; 312: 124138.
[22] Levine B. Regulation of central blood volume and cardiac filling in endurance athletes. the Frank-Starling mechanism as a determinant of orthostatic tolerance. Med Sci Sports Exer 1993; 25: 727731.[Web of Science][Medline]
[23] Convertino V, Montgomery L, Greenleu FJ. Cardiovascular responses during orthostasis: Effect of an increase in VO2max. Aviat Space Environ Med 1984; 55: 702708.[Medline]
[24] Convertino VA, Sather TM, Goldwater D, Alford W. Aerobic fitness does not contribute to prediction of orthostatic intolerance. Med Sci Sports Exer 1989; 18: 551556.
[25] Frederick S, Kosinski D, Grubb BP, Andres F, Hahn H. Comparison of aerobic capacity, parasympathetic modulation, and orthostatic tolerance. Abstract. Clin Auton Res 1995; 5: 334.
[26] Klein K, Bruner H, Jory D, Vogt L, Wegman H. Influence of stature and physical fitness in tilt table and acceleration tolerance. Aerospace Med 1969; 40: 293.[Medline]
[27] Mack G, Convertino A, Nadel E. Effect of exercise training on cardiopulmonary baroreflex control of forearm vascular resistance in humans. Med Sci Sports Exerc 1993; 25: 722726.
[28] Convertino A, Brock P, Keil L, Bernaver E, Greenleaf J. Exercise training induced hypervolemia: Role of plasma albumin, renin and vasopressin. J Appl Physiol 1980; 48: 655659.
[29] Blomquist C and Saltin B. Cardiovascular adaptations to physical training. Annu Rev Physiol 1983; 45: 169.[CrossRef][Web of Science][Medline]
[30] Munir S, Al-Ani M, White M, Townsend J, Coor J. The effect of endurance training on cardiac vagal tone. Clin Aut Res 1995; 5: 99.
[31] Goldsmith R, Bigger T, Steinman R, Fleiss J. Comparison of 24 hour parasympathetic activity in endurance-trained and untrained young men. J Am Coll Cardiol 1992; 20: 552558.[Abstract]
[32] Sacknoff D, Gleim G, Shachenfeud N, Coplan N. Effect of athletic training on heart rate variability. Am Heart J 1994; 127: 12751278.[CrossRef][Web of Science][Medline]
[33] Rasmussen V, Hauns S, Skagen K. Cerebral attacks due to excessive vagal tone in heavily trained persons. Acta Med Scand 1978; 204: 401405.[Medline]
[34] Osswald S, Brooks R, O'Nunain S. Asystole after exercise in healthy persons. Ann Intern Med 1994; 120: 10081011.
[35] Fley JL and Asanle A. Asystole following treadmill exercise in a man without organic heart disease. Arch Int Med 1983; 143: 18211822.
[36] Hirata T, Tano K, Okui T, Mitsuoka T, Hashiba K. Asystole with syncope following strenuous exercise in a man without organic heart disease. J Electrocardiol 1987; 20: 280283.[Medline]
[37] Schlesinger Z. Life threatening vagal reaction to physical fitness test. JAMA 1973; 226: 1119.[CrossRef][Web of Science][Medline]
[38] Suycke E, Card H, Sohol S, Nguyen N, Sung R. Post exertional cardiac asystole in a young man without organic heart disease. Ann Intern Med 1987; 106: 844845.
[39] Lewis T. A lecture on vasovagal syncope and the carotid sinus mechanism. Br Med J 1932; 873876.
[40] Sra J, Jazayeri M, Avitall B, Blanck Z, Akhtar M. Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic syncope with bradycardia or hypotension. N Engl J Med 1993; 328: 10851090.
[41] Petersen M, Price D, Williams T. Short interval VDD pacing does not prevent tilt-induced syncope in patients with cardioinhibitory vasovagal syndrome. PACE 1994; 17: 281282.
[42] Benditt D, Petersen M, Lurie K, Grubb B, Sutton R. Cardiac pacing for prevention of recurrent vasovagal syncope. Ann Int Med 1995; 122: 204209.
[43] Kosinski D and Grubb BP. Neurally-mediated syncope with an update in indications and usefulness of head upright tilt table testing and pharmacologic therapy. Curr Opin Cardiol 1994; 5365.
[44] Natale A, Akhtar M, Jazayeri M. Provocation of hypotension during head up tilt testing in subjects with no history of syncope or presyncope. Circulation 1995; 92: 5458.
[45] Ferrario G, Peci P, Tiberio N, Sgherzi B, Giani P. Long distance runners heart: Is it a condition at risk for malignant vaso-vagal syndrome? (Abstr). PACE 1993; 18: 936.
[46] Benditt DG, Ferguson D, Grubb BP. Tilt table testing for assessing syncope and its treatment: An American College of Cardiology expert consensus document. J Am Coll Cardiol 1996; 28: 263275.[CrossRef][Web of Science][Medline]
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
F. Colivicchi, F. Ammirati, A. Biffi, L. Verdile, A. Pelliccia, and M. Santini Exercise-related syncope in young competitive athletes without evidence of structural heart disease. Clinical presentation and long-term outcome Eur. Heart J., July 2, 2002; 23(14): 1125 - 1130. [Abstract] [Full Text] [PDF] |
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
