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Europace 1999 1(2):146-147; doi:10.1053/eupc.1998.0031
© 1999 by European Society of Cardiology
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CASE REPORT

Pacing-induced left ventricular dysfunction

Relationship with coronary perfusion

C. C. de Cock, L. M. C. van Campen, O. Kamp and C. A. Visser

Department of Cardiology, University Hospital VU Amsterdam, The Netherlands

In a patient admitted with symptomatic complete heart block, a DDD pacemaker was implanted. Prior to implantation, echocardiography showed normal left ventricular function. Shortly after implantation, acute congestive heart failure developed with extensive regional hypo- and akinetic segments in the anteroseptal, anterolateral and apical region. Subsequent perfusion imaging with methoxyiso-buticeisonitrite (MIBI) at rest demonstrated hypoperfusion in the same regions while coronary angiography showed normal epicardial coronary vessels. Thus, impaired regional coronary flow can be associated with cardiac stimulation, inducing marked deterioration of left ventricular function.

Key Words: Cardiac pacing, coronary flow


Correspondence: C. C. de Cock, Department of Cardiology, University Hospital VU, Amsterdam, The Netherlands.


[1] Rosenqvist M, Isaak K, Botvinick E. Relative importance of activation sequence compared to AV synchrony in left ventricular function. Am J Cardiol 1991; 67: 148–156.[CrossRef][Web of Science][Medline]

[2] Karpawich PP, Justice CD, Cavitt DL. Developmental sequelae of fixed-rate ventricular pacing in the immature canine heart: an electrophysiologic, hemodynamic, and histopathologic evaluation. Am Heart J 1990; 119: 1077–1083.[Web of Science][Medline]

[3] Adomian GE and Beazell J. Myofibrillar disarray produced in normal hearts by chronic electrical pacing. Am Heart J 1986; 112: 79–83.[CrossRef][Web of Science][Medline]

[4] Prinzen FW, Cheriex EC, Delhaas T. Asymmetric thickness of the left ventricular wall resulting from asynchronous electric activation: a study in dogs with ventricular pacing and in patients with left bundle branch block. Am Heart J 1995; 130: 1045–1053.[CrossRef][Web of Science][Medline]

[5] Tse HF and Lau CP. Long-term effects of right ventricular pacing on myocardial perfusion and function. J Am Coll Cardiol 1997; 29: 744–749.[Abstract]

[6] Grover M and Glantz SA. Endocardial pacing site effects left ventricular end-diastolic volume and performance in the intact anaesthetized dog. Circ Res 1983; 53: 72–85.[Abstract/Free Full Text]

[7] Little WC, Reeves RC, Arciniegas J. Mechanisms of abnormal intraventricular septal motion during delayed left ventricular activation. Circulation 1982; 65: 1486–1491.[Abstract/Free Full Text]

[8] Hultgren HN, Craige E, Fujii J. Left bundle branch block and mechanical events of the cardiac cycle. Am J Cardiol 1983; 52: 755–762.[CrossRef][Web of Science][Medline]

[9] Grines CL, Bashore TM, Boudoulas H. Functional abnormalities in isolated left bundle branch block: the effect of interventricular asynchrony. Circulation 1989; 79: 845–853.[Medline]

[10] Kolettis TM, Kremastinos DT, Kyriakides ZS. Effects of atrial, ventricular, and atrioventricular sequential pacing on coronary flow reserve. PACE 1995; 18: 1628–1635.

[11] Takeuchi M, Nohtomi Y, Kuroiwa A. Effect of ventricular pacing on coronary blood flow in patients with normal coronary arteries. PACE 1997; 18: 2463–2469.

[12] Kyriakides ZS, Kolettis KTM, Livanis E. Short-term effects of atrial versus atrio-ventricular pacing on myocardial ischaemia in coronary artery disease patients. Eur Heart J 1993; 14: 607–613.[Abstract/Free Full Text]

[13] Fu L, Imai K, Okabe A. A possible mechanism for pacemaker-induced T-wave changes. Eur Heart J 1992; 13: 1173–1179.[Abstract/Free Full Text]

[14] Fouad FM, Slominski JM, Tarazi RC. Left ventricular diastolic function in hypertension: relation to left ventricular mass and systolic function. J Am Coll Cardiol 1984; 3: 1500–1506.[Abstract]

[15] Yasue H, Matsuyama K, Okumura K. Responses of angiographically normal human coronary arteries to intra-coronary injection of acetylcholine by age and segment. Circulation 1990; 81: 482–490.[Abstract/Free Full Text]

[16] Mosseri M, Izak T, Rosenheck S. Coronary angio-graphic characteristics of patients with permanent artificial pacemakers. Circulation 1997; 96: 809–815.[Abstract/Free Full Text]


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This Article
Right arrow Abstract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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ISI Web of Science (1)
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Right arrow Articles by de Cock, C. C.
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