© 2002 by European Society of Cardiology
PACING
PEA I and PEA II based implantable haemodynamic monitor: pre clinical studies in sheep
Biomedical Technology Unit, Bologna University Italy; 1Cardiac Surgery Dept, Bologna University Italy
Manuscript submitted 2 March 2001. Accepted after revision 14 October 2001.
Correspondence: Gianni Plicchi, PhD, Servizio di Tecnologie Biomediche, Policlinico S. Orsola, Via Massarenti 9, 40138, Bologna, Italy. E-mail: tecbio{at}med.unibo.it
Key Words: PEA I, contractility, PEA II, diastolic function
Aims
The aims of this study were first, to demonstrate that Peak Endocardial Acceleration during isovolumic systole (PEA I) is related to positive peak LVdP/dt, while Peak Endocardial Acceleration during isovolumic relaxation time (PEA II) is related to aortic diastolic pressure (ADP) and to negative peak LVdP/dt; and second, to test if the simultaneous recording of PEA I and PEA II offers a new chance to monitor indexes of LV systolic and diastolic function.
Methods
An implantable haemodynamic monitor, based on PEA I and PEA II measurements via a microaccelerometer sensor located in the tip of a pacing lead, screwed into the right ventricle, was tested in nine sheep at baseline and during acute haemodynamic interventions: nitrate (0·1 mg/kg), metaraminol (0·15 mg/kg), dobutamine (5 µg/kg) infusion. ADP, positive and negative peak LVdP/dt were simultaneously recorded by an aortic and left ventricular Millar catheter.
Results
PEA I changes were significantly related to positive peak LVdP/dt changes during dobutamine induced inotropic changes (r=0·83, P< 0·001). PEA II changes were significantly related to both ADP (r=0·91, P< 0·001) and negative peak LVdP/dt changes (r=0·92, P< 0·001) during nitrate induced hypotension and metaraminol induced hypertension.
Conclusion
The simultaneous recording of PEA I and PEA II with an implantable system offers a new chance to monitor indexes of LV systolic and diastolic function.
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