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Europace Advance Access published online on November 6, 2009
Europace, doi:10.1093/europace/eup357
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

CLINICAL RESEARCH

Tpeak–Tend interval and Tpeak–Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype

Konstantinos P. Letsas*, Reinhold Weber, Klaus Astheimer, Dietrich Kalusche and Thomas Arentz

Abteilung Rhythmologie, Herz-Zentrum, Südring 15, 79189 Bad Krozingen, Germany

Aims: The present study investigated whether several ECG markers of ventricular repolarization are associated with ventricular tachycardia/fibrillation (VT/VF) inducibility in subjects with type 1 ECG pattern of Brugada syndrome (BS).

Methods and results: The clinical data of 23 individuals (19 males, age 42.69 ± 14.63) with spontaneous (n = 10) or drug-induced (n = 13) type 1 ECG pattern of BS who underwent programmed ventricular stimulation were analysed. Sustained VT/VF was induced in 17 subjects (74%) and was significantly associated with the presence of spontaneous type 1 ECG of BS (P = 0.012). Among the studied ECG repolarization markers, subjects with inducible VT/VF displayed an increased Tpeak–Tend interval in leads V2 (88.82 ± 15.70 vs. 78.33 ± 4.08 ms, P = 0.02) and V6 (76.33 ± 10.08 vs. 66.66 ± 5.16 ms, P = 0.04) and a greater Tpeak–Tend/QT ratio in lead V6 (0.214 ± 0.028 vs. 0.180 ± 0.014, P = 0.009) compared with those without arrhythmias. Ventricular tachycardia/fibrillation inducibility was not associated with arrhythmic events during a mean follow-up period of 4.61 ± 2.14 years (P = 0.739).

Conclusion: The Tpeak–Tend interval and Tpeak–Tend/QT ratio were associated with VT/VF inducibility in BS. The utility of Tpeak–Tend/QT ratio as a new marker of arrhythmogenesis in BS requires further studies, including a large number of patients.

Key Words: Tpeak–Tend interval, Tpeak–Tend/QT ratio, Brugada syndrome, Ventricular arrhythmias, Electrophysiological study

* Corresponding author. Tel: +49 302106843854, Fax: +49 76334022429, Email: k.letsas{at}mail.gr

Manuscript submitted 12 August 2009. Accepted after revision 15 October 2009.


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