Europace Advance Access published online on July 9, 2009
Europace, doi:10.1093/europace/eup187
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CLINICAL RESEARCH
Electrophysiological findings in patients with isolated left ventricular non-compaction
1 Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland; 2 Division of Cardiology, Kantonsspital Luzern, Luzern, Switzerland; 3 Center for Integrative Human Physiology, University of Zurich, Zürich, Switzerland
Aims: Patients with isolated left ventricular non-compaction (IVNC) are at high risk for developing ventricular tachyarrhythmias. However, no analysis of invasive electrophysiological (EP) findings in these patients has yet been performed.
Methods and results: We performed a retrospective analysis of EP findings in 24 patients with IVNC. Ventricular tachyarrhythmias were inducible in nine patients; of these, two patients had sustained monomorphic ventricular tachycardia (VT) and two patients had ventricular fibrillation. No specific electrocardiographic or echocardiographic finding was predictive of VT inducibility. Three of the 9 patients with inducible VT experienced ventricular tachyarrhythmias during the follow-up of 61.4 ± 50 months, whereas no tachyarrhythmias or sudden deaths were noted in 12 patients without inducible VT during the follow-up of 30 ± 19 months (3 patients in the latter group were lost to follow-up). Supraventricular tachyarrhythmias were inducible in seven patients.
Conclusion: Our present study provides the first comprehensive analysis of EP findings in patients with IVNC. Ventricular and supraventricular arrhythmias can readily be induced in these patients, whereas the inducibility of a sustained monomorphic VT is relatively low. Further studies including long-term follow-up are required to investigate the role of EP testing for arrhythmic risk stratification in these patients.
Key Words: Non-compaction, Cardiomyopathy, Electrophysiology, Ventricular tachycardia, Implantable cardioverter defibrillator
* Corresponding author. Tel: +41 44 255 35 65, Fax: +41 44 255 44 01, Email: firat.duru{at}usz.ch
Manuscript submitted 13 April 2009. Accepted after revision 15 June 2009.
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