Europace Advance Access first published online on November 12, 2008
This version published online on November 25, 2008
Europace, doi:10.1093/europace/eun307
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CLINICAL RESEARCH
Evaluation of spatiotemporal organization of persistent atrial fibrillation with time- and frequency-domain measures in humans
1 Department of Cardiology, Rikshospitalet University Hospital, Sognsvannsveien 20, 0027 Oslo, Norway; 2 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Aims: Areas with complex fractionated electrograms are commonly targeted during ablation of persistent atrial fibrillation (AF). These signals are, however, found in most sampled areas of the left atrium (LA), implying the need for further differentiation.
Methods and results: Electrograms were recorded over 60 s at eight different LA endocardial sites in 10 patients with persistent AF, using a fully automated algorithm. These were analysed in sequential 2 s segments for activity, mean amplitude, continuous activity percentage, and dominant frequency (DF). All three time-domain measures differed significantly between the LA sites (P < 0.001), whereas DF did not. Activity, continuous activity percentage, and mean activity–amplitude were highest in the mid-coronary sinus and lowest on the posterior wall. In a pairwise analysis, there were significant differences in activity between all locations (P < 0.001–0.044). To visualize the spatiotemporal activity patterns, activity was plotted against amplitude. This revealed distinct activity patterns with large intra- and inter-individual differences.
Conclusion: There are significant activity gradients and distinct activity patterns within the LA in humans with persistent AF. Further work is required, however, to determine whether these findings signify areas with different roles and importance in AF maintenance.
Key Words: Atrial fibrillation, Mapping, Electrograms, Spectral analysis, Catheter ablation
* Corresponding author. Tel: +47 2307 2016, Fax: +47 2307 3917, Email: rfb123{at}hotmail.com
This paper has been versioned to correct an error in the legend to figure 3 part B.
Manuscript submitted 6 August 2008. Accepted after revision 21 October 2008.
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