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Europace Advance Access published online on July 11, 2008
Europace, doi:10.1093/europace/eun180
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

SHORT COMMUNICATION

Reduction of complex ventricular ectopy and improvement in exercise capacity with flecainide therapy in Andersen–Tawil syndrome

David J. Fox*, George J. Klein, Angelika Hahn, Allan C. Skanes, Lorne J. Gula, Raymond K. Yee, Rajesh N. Subbiah and Andrew D. Krahn*

Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada

Andersen–Tawil syndrome (ATS) is a rare inherited autosomal disorder characterized by the clinical triad of ventricular arrhythmias, hypokalaemic periodic paralyses, and skeletal developmental abnormalities, resulting in dysmorphic features. Although ATS patients have a high incidence of ventricular arrhythmias, the occurrence of sudden cardiac death is rare. In this report, we describe the successful use of flecainide in an ATS patient with a considerable ventricular arrhythmia burden who had not demonstrated any response to conventional β-blocker therapy used in conjunction with potassium (K+) supplementation.

Key Words: Flecainide, Exercise, Repolarization, Ectopy

* Corresponding authors. London Health Sciences Centre, University Campus, 339 Windermere Road, Room 3HE-6, London, Ontario, Canada N6A 5A5. Tel: +1 519 663 3746; fax: +1 519 663 3786 (A.D.K.), Tel/fax: +1 519 685 8500 (D.J.F.). E-mail address: akrahn{at}uwo.ca (A.D.K.) or david.j.fox{at}talk21.com (D.J.F.)

Manuscript submitted 25 May 2008. Accepted after revision 10 June 2008.


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