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Europace Advance Access published online on July 8, 2008
Europace, doi:10.1093/europace/eun177
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

REVIEW

Ventricular optimization of biventricular pacing: a systematic review

Sern H. Lim*, Gregory Y.H. Lip and John E. Sanderson

University Department of Medicine, City Hospital, Birmingham B18 7QH, UK

Biventricular pacing has been shown to improve the overall clinical outcomes in patients with systolic heart failure and ventricular conduction delay on electrocardiogram. As correction of ventricular dyssynchrony is the putative mechanism of benefit, biventricular pacing is also termed as cardiac resynchronization therapy. The development of separate programmability of right and left ventricular output has led to a growing number of reports on the potential benefit of optimization of cardiac resynchronization by sequential biventricular pacing with different techniques and endpoints. This systematic review summarizes the current data for the optimization of sequential (V–V delay) compared with (default) simultaneous biventricular pacing in heart failure.

Key Words: Biventricular pacing, Systolic heart failure, Optimization, Cardiac resynchronization

* Corresponding author: Department of Cardiovascular Medicine, University Hospital Birmingham, Birmingham B15 2TT, UK. Tel: +44 121 507 5080. E-mail address: hsern{at}doctors.net.uk

Manuscript submitted 25 March 2008. Accepted after revision 10 June 2008.


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