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Europace Advance Access published online on May 14, 2008
Europace, doi:10.1093/europace/eun127
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

MINI REVIEW

Update on the pathophysiological basics of cardiac resynchronization therapy

Angelo Auricchio1,2,* and Frits W. Prinzen1,2

1 Division of Cardiology, Fondazione Cardiocentro Ticino, Via Tesserete 48, 6900 Lugano, Switzerland; 2 Department of Physiology, Maastricht University, Maastricht, The Netherlands

Cardiac resynchronization therapy is an established treatment for patients with severe heart failure and ventricular conduction disturbance. Cardiac resynchronization therapy improves cardiac pump function and clinical status, and reduces morbidity and mortality. This electrical treatment for heart failure has also contributed enormously to the understanding of the pathophysiology of ventricular conduction disturbance. This article highlights the latest findings about the pathophysiology of ventricular conduction disturbance and pacing as well as that of resynchronization, with emphasis on the role of regional mechanical performance in triggering remodeling processes involved and on the selection of patients using mechanical dyssynchrony.

Key Words: Cardiac resynchronization therapy, Heart failure, Physiology, Ventricular activation, Echocardiography

* Corresponding author. Tel: +41 91 805 3340; fax: +41 91 805 3167. E-mail address: angelo.auricchio{at}cardiocentro.org

Manuscript submitted 21 March 2008. Accepted after revision 22 April 2008.


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