Skip Navigation


Europace Advance Access originally published online on May 21, 2007
Europace 2007 9(9):751-756; doi:10.1093/europace/eum081
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
9/9/751    most recent
eum081v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gould, P. A.
Right arrow Articles by Kaye, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gould, P. A.
Right arrow Articles by Kaye, D. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

CARDIAC RESYNCHRONISATION THERAPY

Improvement in cardiac adrenergic function post biventricular pacing for heart failure

Paul A. Gould1, Grace Kong2, Victor Kalff2, Stephen J. Duffy3, Andrew J. Taylor3, Michael J. Kelly2 and David M. Kaye1,*

1 Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne VIC 3004, Australia; 2 Department of Nuclear Medicine, Alfred Hospital, Melbourne, Australia; 3 Alfred Heart Centre, Alfred Hospital, Melbourne, Australia

Aims We investigated whether biventricular (BiV) pacing favourably affects cardiac sympathetic activity in heart failure (HF).

Methods and results In 10 HF patients treated with BiV pacing, we assessed cardiac sympathetic activity by metaiodobenzylguanidine (123I-MIBG) imaging. Patients were randomized in a double-blinded crossover fashion, for two weeks of either inactivation of BiV pacing or BiV pacing, with crossover to the alternate group for a further two weeks. After randomization blocks, cardiac 123I-MIBG imaging and a 6 min walk test were performed. BiV pacing was associated with significant improvements in cardiac 123I-MIBG uptake reflected by increases in early (BiV 1.71 ± 0.09 vs. non-BiV 1.63 ± 0.06, P = 0.03) and late (at 4 h) heart to mediastinal ratio of uptake (BiV 1.54 ± 0.08 vs. non-BiV 1.45 ± 0.06, P = 0.03). Additionally, pulmonary 123I-MIBG uptake, measured as lung to mediastinal ratio, significantly improved (P = 0.009). Six-minute walk and systolic blood pressure tended to improve with BiV vs. non-BiV pacing (P = 0.09).

Conclusion In patients with stable HF, BiV pacing is associated with long-term improvements in cardiac sympathetic nerve activity, as reflected by improvements in cardiac 123I-MIBG uptake. This is a potential mechanism for morbidity and mortality benefits observed in larger studies.

Key Words: Biventricular pacing, Heart failure, Sympathetic activity, Cardiac 123I-MIBG scanning

* Corresponding author. Tel: +61 3 9207 1044; fax: +61 3 9207 1075. E-mail address: david.kaye{at}baker.edu.au

Manuscript submitted 27 August 2006. Accepted after revision 2 April 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EuropaceHome page
H. Burri, H. Sunthorn, A. Somsen, E. Fleury, C. Stettler, D. Shah, and A. Righetti
Improvement in cardiac sympathetic nerve activity in responders to resynchronization therapy
Europace, March 1, 2008; 10(3): 374 - 378.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.