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Europace Advance Access originally published online on March 29, 2007
Europace 2007 9(5):285-288; doi:10.1093/europace/eum005
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

VENTRICULAR ARRHYTHMIA

Radiofrequency catheter ablation of premature ventricular complexes improved left ventricular function in a non-responder to cardiac resynchronization therapy

Csaba Herczku, Csaba Kun, Istvan Edes and Zoltan Csanadi*

Institute of Cardiology, University of Debrecen, Móricz Zsigmond krt. 22, H-4032 Debrecen, Hungary

Frequent premature ventricular complexes (PVCs) have been demonstrated to cause tachycardiomyopathy in some individuals with a structurally normal heart. We report a patient with severe congestive cardiomyopathy which did not respond to cardiac resynchronization therapy (CRT). Ambulatory monitoring and interrogation of the device memory revealed frequent monomorphic PVCs that were considered a potential cause of the failure of CRT. Radiofrequency ablation of the focus at the postero-inferior left ventricle eliminated the arrhythmia, with a resultant rapid improvement in the clinical status and echo parameters. As PVCs are often associated with severe heart failure, the presence of frequent extrasystoles may be an underrecognized cause of a non-response to resynchronization therapy.

Key Words: Radiofrequency catheter ablation, Premature ventricular complexes, Cardiac resynchronization therapy, Non-responder

* Corresponding author. Tel: +36 52 411717/54576; fax: +36 52 414928. E-mail address: drcsanadi{at}hotmail.com

Manuscript submitted 26 September 2006. Accepted after revision 10 December 2006.


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