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Europace Advance Access originally published online on March 23, 2007
Europace 2007 9(5):278-280; doi:10.1093/europace/eum033
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

VENTRICULAR ARRHYTHMIA

Doxorubicin-induced ventricular arrhythmia treated by implantation of an automatic cardioverter-defibrillator

Tomasz Rudzinski*, Michal Ciesielczyk, Wojciech Religa, Zbigniew Bednarkiewicz and Maria Krzeminska-Pakula

2nd Department of Cardiology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland

Anthracyclines are a group of potent antitumour agents and cardiotoxicity is an important factor limiting their therapeutic effectiveness. Although cardiomyopathy is the most widely recognized type of cardiotoxic reaction, early arrhythmia following anthracycline administration may be of clinical significance as well. We report a case of ventricular tachycardia causing cardiac arrest in a female treated with doxorubicin as adjuvant therapy of breast cancer. Due to recurrence of the arrhythmia and a desire to continue chemotherapy, an automatic cardioverter-defibrillator was implanted with excellent effect.

Key Words: Anthracyclines, Cardiotoxicity, Arrhythmia

* Corresponding author. Tel: +48 502 067 858; fax: +48 502 067 858. E-mail address: tomek_rudzinski{at}op.pl

Manuscript submitted 12 October 2006. Accepted after revision 9 February 2007.


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