Europace Advance Access originally published online on March 13, 2007
Europace 2007 9(4):252-255; doi:10.1093/europace/eum023
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BRUGADA SYNDROME
Prevalence of Brugada sign in patients presenting with palpitation in southern Iran
Cardiology Department, Namazee Hospital, Shiraz University of Medical Sciences, PO Box 71935-1334, Shiraz, Islamic Republic of Iran
Aims Brugada syndrome is a cardiac channel abnormality that is associated with a high risk of ventricular fibrillation and sudden cardiac death and characterized by an electrocardiographic pattern of right bundle branch block and transient or persistent ST-segment elevation in leads V1–V3. No data regarding the frequency of Brugada syndrome exist in an Iranian population. The aim of this study was to determine the frequency of Brugada-type ECG pattern in southern Iran.
Methods and results All patients presenting with palpitation were enrolled in the study. A Brugada-type ECG pattern was determined according to the criteria recommended by European Heart Association Molecular Basis of Arrhythmias Study Group. A total of 3895 patients (mean age 38.2 ± 11.9 years, 54% women) met all study criteria. One hundred patients (2.56%) had Brugada-type ECG pattern. Of these, 21 patients (0.54%) had definite Brugada sign (Type 1 or Types 2 and 3 with conversion to Type 1 following procainamide test). Of 21 patients with definite Brugada sign, eight had Brugada syndrome, four had history of syncope, two had coved-type ECG in the family, one had polymorphic ventricular tachycardia, and one had history of sudden cardiac death in the family. Five patients underwent ICD implantation. The incidence of a Brugada-type ECG pattern was 2.43% in subjects between 17 and 30 years and 0.13% in subjects >30 years (P = 0.01).
Conclusion Frequency of Brugada sign in an Iranian population presenting with palpitation is greater than some European countries and lower than a Japanese urban population.
Key Words: Arrhythmia, Brugada Syndrome, Palpitation
* Corresponding author. Tel: +0912 108 0413; fax: +98 711 6279733. E-mail address: draslani{at}yahoo.com
Manuscript submitted 29 September 2006. Accepted after revision 31 December 2006.
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