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Europace Advance Access originally published online on October 18, 2007
Europace 2007 9(12):1218-1221; doi:10.1093/europace/eum224
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

EXPERIMENTAL STUDIES

Electrophysiological consequence of adipose-derived stem cell transplantation in infarcted porcine myocardium

Parwis Fotuhi1, Yao-Hua Song2 and Eckhard Alt1,2,*

1 Department of Medicine, Section of Cardiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA; 2 Department of Molecular Pathology, M.D. Anderson Cancer Center, University of Texas, Box 951 7435 Fannin Street, Houston, TX 77030, USA

Aims: Aim of this study was to investigate the effect of intracoronary administration of freshly isolated adipose-derived mononuclear cells (ADMCs) on myocardial vulnerability to arrhythmia induction after infarction.

Methods and results: A transmural myocardial infarction in an experimental porcine model was induced by occlusion of the mid-left anterior descending artery with an angioplasty balloon for 3 h. Upon reperfusion, a cellular suspension with freshly isolated ADMCs (1.5 x 106 cells/kg BW) or vehicle alone was injected into the infarct artery. All animals underwent a programmed ventricular stimulation at 8 weeks follow-up for possible induction of ventricular arrhythmias using a train of 8 S1 stimuli. Cell injections did not cause acute ventricular arrhythmia, bradycardia, or conduction block. The cycle length of the ventricular arrhythmia was compared at 1 and 10 s following its induction. Despite comparable infarct size in both groups, we found that the cycle length of the induced ventricular arrhythmia in the ADMC-treated group was significantly longer compared with control animals (P < 0.05). We also found that extra-stimuli were required for arrhythmia induction in the ADMC-treated group compared with control animals.

Conclusion: Freshly isolated autologous stem cell therapy is not proarrhythmic in pigs.

Key Words: Stem cell, Arrhythmia, Myocardial vulnerability

* Corresponding author. Tel: +1 713 834 6106; fax: +1 713 834 6105. E-mail address: ealtmd{at}aol.com

Manuscript submitted 6 August 2007. Accepted after revision 12 September 2007.


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