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Europace Advance Access originally published online on October 11, 2007
Europace 2007 9(11):1077-1080; doi:10.1093/europace/eum221
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

ELECTROCARDIOLOGY

Prevalence of Brugada sign in a Greek tertiary hospital population

Konstantinos P. Letsas*, Gerasimos Gavrielatos, Michalis Efremidis, Stavros P. Kounas, Gerasimos S. Filippatos, Antonios Sideris and Fotios Kardaras

Second Department of Cardiology, Evangelismos General Hospital of Athens, 45-47 Ipsilantou St., 10676 Athens, Greece

Aims: The purpose of the present study was to determine for the first time the prevalence of Brugada-type electrocardiographic (ECG) pattern (Brugada sign) in unselected individuals served by an urban Greek tertiary hospital during a 4-year time period.

Methods and results: Among 11 488 individuals (6640 males, 4848 females), 25 (23 males, 2 females, aged 36.8 ± 19.2 years) were found to display the Brugada sign (0.22%). Two cases exhibited the diagnostic type 1 ECG pattern (0.02%) and 23 subjects fulfilled the ECG criteria for type 2 or 3 patterns (0.2%). The incidence of Brugada sign was higher among men (0.34%) than in women (0.04%). Structural heart disease was established in four cases (one of them exhibiting a type 1 ECG pattern). Twenty-one individuals (19 males, 2 females, aged 29.7 ± 10.7 years) without structural heart disease displaying Brugada-type ECG features (4 cases with spontaneous or procainamide-induced type 1 ECG pattern) were subsequently selected and closely followed up for 24 ± 12 months. No mortality or life-threatening ventricular arrhythmias were recorded during this period.

Conclusion: The Brugada-type ECG pattern is infrequently seen in a Greek hospital-based population. All subjects with Brugada sign and structurally normal hearts displayed a benign clinical course without arrhythmic events during a relatively long follow-up period.

Key Words: Brugada syndrome, Prevalence, Prognosis, Sudden cardiac death

* Corresponding author: Tel: +30 210 6843854; fax: +30 210 7217687. E-mail address: k.letsas{at}mail.gr

Manuscript submitted 3 June 2007. Accepted after revision 9 July 2007.


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