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Europace 2005 7(s2):S83-S92; doi:10.1016/j.eupc.2005.03.017
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© 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.

Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria

Vincent Jacquemeta,*, Nathalie Viragb and Lukas Kappenbergerc

aSignal Processing Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL) Station 11, CH-1015 Lausanne, Switzerland; bMedtronic Europe CH-1131 Tolochenaz, Switzerland; cService de Cardiologie, Centre Hospitalier Universitaire Vaudois (CHUV) CH-1011 Lausanne, Switzerland

AIM: To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atrial fibrillation (AF).

METHODS: A biophysically based computer model was used to: (1) study the relationship between wavelength and AF perpetuation in the presence of multiple re-entrant wavelets, (2) evaluate the performance of different existing methods for wavelength estimation in the presence of different arrhythmogenic substrates, and (3) document the impact of either heterogeneities in refractoriness or the presence of a mother rotor on wavelength estimation.

RESULTS: The simulations confirmed that the wavelength must be below a critical value for AF to be sustained, when the perpetuation mechanism relies on multiple re-entrant wavelets. The estimated value of wavelength was not the same for all methods tested and depended in part on the nature of the spatio-temporal organization of the AF dynamics.

CONCLUSION: A priori information about the underlying wavelet dynamics is needed for a correct interpretation of the cardiac wavelength as estimated by the current clinical methods.

Key Words: atrial fibrillation, wavelength, multiple wavelets, computer modelling

*Corresponding author. Tel.: +41 21 693 4754; fax: +41 21 693 7600. E-mail address: vincent.jacquemet{at}epfl.ch (V.Jacquemet).


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