Skip Navigation

Europace 2005 7(3):289; doi:10.1016/j.eupc.2005.02.009
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Res, J. C.J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Res, J. C.J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.

CP09: BIFOCAL PACING IN CLASS III CHF PATIENTS IS SUCCESFUL. INTERIM REPORT ON THE ONGOING BRIGHT STUDY

Jan C.J. Res*, Marcel. J.J.A. Bokern on behalf of the BRIGHT-Investigators

*Zaansch Medisch Centrum De Heel, Zaandam; Waterland Hospital Purmerend, NL

Bifocal right (BRIGHT) pacing is an alternative of biventricular pacing in CRT. The BRIGHT study is ongoing randomized cross-over CRT pacing study in class III CHF pts: simultaneous pacing of the apex and the outflow tract. Forty pts are enrolled in this study. Pts characteristics are: age 69±9 years, 11 female, NYHA class 3,0±0,3; EF 24±6% and QRS-width179±19 ms.

METHODS: Minnesota quality of life score, LV ejection fraction (EF), 6-minute walk test and NYHA class were major endpoints, measured before randomisation and after 3 months of back up pacing (VVI 40 bpm at RV Apex) or BRIGHT pacing. 26 pts with a minimum follow up of 7 months were analysed. 7 pts are excluded from analysis: 4 due to early death (before or just after randomisation), and 3 pts had procedure related problems.

RESULTS: Functional Class improved during BRIGHT pacing to 2,4±0,6 vs 2,8±0,7 control treatment (p < 0,03). The quality of life score tended to improve by lowering from 32 ± 19 to 23 ± 19 (p < 0,02) during BRIGHT pacing, while it did not change in the control 33 ± 22 points. The EF was before randomisation 29±11% and was higher: 36±12 % after BRIGHT pacing vs control treatment: 24±12% (p= 0,0007). The grading of the mitral insufficiency was similar during BRIGHT vs. control back up pacing: 1,7 ± 0,9 vs. 1,7 ± 0,9 (p =NS) The 6-min. walk test was a increased after BRIGHT pacing vs. the control group: 476 ± 99 m vs. 412 ± 132 m (p = 0.07). Five pts could not tolerate control pacing after the BRIGHT pacing.

CONCLUSION: In this small group of pts benefits are clear in favour of BRIGHT pacing: a few pts could not tolerate spontaneous conduction after a period of BRIGHT pacing. Furthermore improvement was seen in EF, quality of life scores and functional class. Bifocal right ventricular pacing is a good alternative for standard CRT pacing in patients with severe CHF.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.