© 2004 by European Society of Cardiology
REVIEW
Evaluation of body weight as a predictive factor for transvenous ventricular defibrillation characteristics
Wessex Cardiothoracic Centre Southampton, UK
AIMS: To investigate the correlation between body weight and defibrillation threshold (DFT) for transvenous lead systems using a porcine model.
METHODS AND RESULTS: Twenty-eight pigs were anaesthetised and DFTs assessed in single and dual coil configurations using a four-reversal binary search method. DFT was correlated with body weight in the RV
Can and RV
SVC + Can configurations. A Pearson correlation coefficient and a two-sided p-value were calculated. A positive correlation exists between body weight and DFT in RV
Can (r=0.66, p<0.000) and RV
SVC + Can (r=0.44, p=0.018).
CONCLUSION: There is a significant correlation between body weight and DFT in swine. This tends to be greater in the two-electrode than in the three-electrode configuration. With these and previous human observations, one may predict a higher DFT in heavy individuals and make appropriate procedural adjustments.
Key Words: implantable cardioverter defibrillator, defibrillation threshold, ventricular arrhythmia, fibrillation, body weight
*Corresponding author. C/O Dr Morgan's Secretary, Mailpoint 46, Southampton General Hospital, Tremona Rd, Southampton SO17 1SX, UK. Tel.: +44-2380-798676; fax: +44-2380-798942. E-mail address: johnpaisey{at}doctors.org.uk (J.R. Paisey).
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