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Europace 2003 5(4):371-373; doi:10.1016/S1099-5129(03)00090-4
© 2003 by European Society of Cardiology
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CASE REPORT

Unusual response to the ajmaline test in a patient with Brugada syndrome

J. Castro Hevia, F. Dorticos Balea, M. Dorantes Sánchez, R. Zayas Molina and M. A. Quiñones Pérez

Arrhythmia Unit, Cardiovascular Surgery and Cardiology Institute Havana, Cuba

We present a Brugada syndrome patient who suffered an aborted sudden death. The ajmaline test (1 mg/kg body weight) induced accentuated alternans ST-segment elevation in V1–V2 without ventricular arrhythmias. It could represent silent ischaemia not detected before, failure of myocardial regions to repolarize in alternate beats due to transmural dispersion of conduction and refractoriness in the right ventricular outflow tract or a rate dependent sodium channel block by ajmaline.

We need more studies to know whether this electrocardiographic sign is a risk factor for life-threatening ventricular arrhythmias in Brugada syndrome patients.

Key Words: Brugada syndrome, ajmaline test, alternans ST-segment elevation

Correspondence: Dr Jesús Castro Hevia, Arrhythmia Unit, Cardiovascular Surgery and Cardiology Institute, Ave Goss #534 apto 4, Víbora CP: 10500, C. Havana, Cuba. Tel.: +53-7-40-40-11; Fax: +53-7-33-14-35; E-mail: jcastroh{at}infomed.sld.cu


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