Europace Advance Access originally published online on May 2, 2009
Europace 2009 11(8):1032-1036; doi:10.1093/europace/eup103
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Biomarkers in Atrial Fibrillation
Plasma YKL-40, a new biomarker for atrial fibrillation?
1 Faculty of Health Sciences, Department of Cardiology, Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark; 2 Department of Cardiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark; 3 Department of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; 4 Department of Infectious Diseases, The Centre of Inflammation and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 5 The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; 6 Faculty of Health Sciences, Department of Surgery and Medicine, University of Copenhagen, Copenhagen, Denmark
Aims: The aim of this study was to determine changes in a new potential biomarker plasma YKL-40 in patients with atrial fibrillation (AF) before and after electrical cardioversion (CV).
Methods and results: Plasma concentrations of YKL-40 were measured in 56 patients (mean age 65 years, range 34–84) with persistent AF (lasting mean 128 days, range 14–960), in 19 age-matched patients with permanent AF, and in 19 healthy subjects. The patients with persistent AF underwent CV. Plasma YKL-40 was measured prior to CV, and at follow-up after 24 h, 30 and 180 days. Patients with persistent AF had lower plasma YKL-40 than patients with permanent AF [70 µg/L (42–105)] vs. [138 µg/L (48–225)] (P = 0.003), and higher levels than healthy subjects [41 µg/L (29–52)] (P = 0.001). Patients (n = 22) who were still in sinus rhythm (SR) at follow-up 30 days after CV had unchanged plasma YKL-40 compared with baseline levels. The baseline levels of YKL-40 were correlated to the levels of IL-6, but not to high sensitivity C-reactive protein.
Conclusion: Patients with AF have significantly elevated levels of YKL-40. YKL-40 was not a significant predictor of successful CV to SR. Plasma levels of YKL-40 did not fall after restoration of SR.
Key Words: Atrial fibrillation, Electrical cardioversion, Inflammation, YKL-40, Interleukin-6
* Corresponding author. Tel:+45 35 45 28 17, Email: jesper.hastrup.svendsen{at}rh.regionh.dk
Manuscript submitted 15 January 2009. Accepted after revision 4 April 2009.
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