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Europace Advance Access originally published online on March 18, 2009
Europace 2009 11(7):896-901; doi:10.1093/europace/eup064
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Obstructive Sleep Apnoea and Recurrence of Atrial Fibrillation

Predictive value of obstructive sleep apnoea assessed by the Berlin Questionnaire for outcomes after the catheter ablation of atrial fibrillation

Karuna Chilukuri1, Darshan Dalal1, Joseph E. Marine1, Daniel Scherr1,2, Charles A. Henrikson1, Alan Cheng1, Saman Nazarian1, David Spragg1, Ronald Berger1 and Hugh Calkins1,*

1 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2 Division of Cardiology, Department of Medicine, Medical University of Graz, Austria

Aims: Obstructive sleep apnoea (OSA) is a risk factor for atrial fibrillation (AF) recurrence after catheter ablation. The purpose of this study is to determine whether OSA assessed by the simple tool, the Berlin Questionnaire (BQ), is useful in predicting the efficacy of catheter ablation of AF.

Methods and results: The patient population consisted of 210 consecutive patients [mean age 58 ± 10 years, 167 (80%) male, 119 (57%) paroxysmal] who underwent catheter ablation of AF and completed the BQ. Clinical success was defined as at least 90% reduction in AF burden after 3-month blanking period. Mean duration of follow-up was 25 ± 12 months. One hundred and one of the 118 (85%) patients at low risk for OSA had clinical success as opposed to 64 of the 92 (70%) patients at high risk for OSA on BQ (P = 0.005). On multivariate analysis, only high-risk for OSA on BQ emerged as an independent predictor of procedural failure (OR 4.53, CI: 1.21–16.87, P = 0.02).

Conclusion: High risk of OSA on BQ predicts procedural failure after catheter ablation of AF. We recommend the use of BQ for risk-stratifying patients for OSA prior to AF ablation procedures and to identify patients for formal sleep study assessment.

Key Words: Berlin Questionnaire, Sleep apnoea, Atrial fibrillation, Catheter ablation, Efficacy

* Corresponding author. The Johns Hopkins Hospital, 600 North Wolfe Street, Carnegie 530, Baltimore, MD 21287-0409, USA. Tel: +1 410 955 7405, Fax: +1 410 614 1345, Email: hcalkins{at}jhmi.edu

Manuscript submitted 14 November 2008. Accepted after revision 18 February 2009.


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