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Europace Advance Access originally published online on April 6, 2009
Europace 2009 11(5):662-664; doi:10.1093/europace/eup077
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

SHORT COMMUNICATIONS

Usefulness of C-reactive protein in predicting early and late recurrences after atrial fibrillation ablation

Nicolas Lellouche1,*, Frederic Sacher2, Matthew Wright2, Isabelle Nault2, Jean Brottier3, Sébastien Knecht2, Seiichiro Matsuo2, Oliver Lomas2, MéLèZe Hocini2, Michel Haïssaguerre2 and Pierre Jaïs2

1 Hôpital Henri Mondor Fédération de Cardiologie, Assistance Publique Hôpitaux de Paris, Université de Médecine Paris XII, Créteil, France; 2 From the Hôpital Cardiologique du Haut-Lévêque and the Université Victor Segalen Bordeaux II, Bordeaux, France; 3 Service de Biochimie Hôpital Cardiologique du Haut-Lévêque and the Université Victor Segalen Bordeaux II, Bordeaux, France

We studied the C-reactive protein level and its predictive value for early and late arrhythmia recurrences after atrial fibrillation (AF) ablation. We analysed data from 125 consecutive patients (52% with paroxysmal AF) who underwent a first AF ablation. C-reactive protein level was determined at baseline and at Days 1, 2, and 3 post-AF ablation. An early recurrence (ER) was defined as any arrhythmia occurring within the first month following the index ablation. Sixty-eight patients (54%) experienced ER. Twenty-nine patients were re-ablated for ER within the first month and were not included for the long-term follow-up analysis. Of the remaining 96 patients, 59 (61%) experienced late recurrences. C-reactive protein level increased significantly after AF ablation with a peak (40 ± 32 mg/L) occurring 2 days after the index procedure. Patients without ER had a significant higher C-reactive protein level (49 ± 52 vs. 32 ± 22 mg/L, P=0.02) compared with patients without ER. However, the C-reactive protein level was similar in patients with or without late recurrences. C-reactive protein level was the only independent predictor of ERs (P = 0.03). C-reactive protein level increased significantly after AF ablation. High C-reactive protein level was associated with fewer early arrhythmia recurrences. No relationship was found between C-reactive protein level and late arrhythmia recurrences.

* Corresponding author. Tel: +33149812111, Fax: +33149814224, Email: nicolellouche{at}yahoo.com

Manuscript submitted 27 November 2008. Accepted after revision 11 March 2009.


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