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Europace Advance Access originally published online on April 6, 2009
Europace 2009 11(5):650-656; doi:10.1093/europace/eup079
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Non-invasive Electrophysiology and Risk Stratification

Prevalence of Brugada sign and syndrome in patients presenting with arrhythmic symptoms at a Heart Rhythm Clinic in Singapore

Novalia P. Sidik, Chwee N. Quay, Fong C. Loh and Lin Y. Chen*

Cardiovascular Division, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Level 3, Singapore 119074, Republic of Singapore

Aims: Southeast Asia is endemic for Brugada syndrome; however, its prevalence in Singapore is unknown. We aimed to determine the prevalence of Brugada sign [Types 1, 2, and 3 Brugada electrocardiogram (ECG)] and syndrome at an arrhythmia clinic in Singapore.

Methods and results: Patients who presented with pre-syncope, syncope, and/or palpitations without a known cause at an arrhythmia clinic between 2005 and 2007 were included in the study. The study criteria were met by 392 patients (age: 49.6 ± 19.1 years, 55.9% male); 675 patients were excluded because they were referred for the management of known diagnoses. The 12-lead ECGs of these patients were analysed and clinical information was abstracted. Brugada sign was observed in 28 patients, and 12 patients were determined to have Brugada syndrome (age: 36.3 ± 15.4 years, 100% male), yielding a prevalence of 7.1% [95% confidence interval (CI): 4.8–10.2] and 3.1% (95% CI: 1.6–5.3), respectively. The prevalence rates of patients with Type 1, Type 2, and Type 3 Brugada signs were 4.8% (95% CI: 2.9–7.5), 1.8% (95% CI: 0.7–3.6), and 0.5% (95% CI: 0.06–1.8), respectively. Over 30.4 person-years of follow-up, there was one inappropriate defibrillation shock but no appropriate shocks or sudden cardiac deaths among patients with Brugada sign or syndrome.

Conclusion: The prevalence of both Brugada sign and syndrome in a hospital-based population in Singapore was found to be high. Further population-based investigation is warranted to confirm these findings.

Key Words: Prevalence, Brugada-type electrocardiogram, Brugada syndrome, Southeast Asia

* Corresponding author. Tel: +65 6772 5260, Fax: +65 6872 2998, Email: mdccly{at}nus.edu.sg

Manuscript submitted 21 January 2009. Accepted after revision 11 March 2009.


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