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Europace Advance Access originally published online on December 24, 2008
Europace 2009 11(3):328-331; doi:10.1093/europace/eun366
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Electrophysiology-Spectral Analysis of Arrhythmias

Spectral analysis of intracardiac electrograms during induced and spontaneous ventricular fibrillation in humans

Juan José Sánchez-Muñoz1,*, José Luis Rojo-Álvarez2, Arcadi García-Alberola1, Estrella Everss2, Felipe Alonso-Atienza2, Mercedes Ortiz3, Juan Martínez-Sánchez1, Javier Ramos-López2 and Mariano Valdés-Chavarri1

1 Arrhythmia Unit, Hospital Universitario Virgen de la Arrixaca de Murcia, El Palmar, Murcia 30120, Spain; 2 Department of Signal Theory and Communications, University Rey Juan Carlos, Spain; 3 Arrhythmia Unit, Hospital General Universitario Gregorio Marañón, Spain

Aims: Very limited data are available on the differences between spontaneous and induced episodes of ventricular fibrillation (VF) in humans. The aim of the study was to compare the spectral characteristics of the electrical signal recorded by an implantable cardioverter defibrillator (ICD) during both types of episodes.

Methods and results: Thirteen ICD patients with at least one spontaneous and one induced VF recorded by the device were included in the study. A spectral representation was obtained for the first 3 s of the intracardiac unipolar electrogram during VF. The dominant frequency (fd), the peak power at fd, an organization index (OI), a bandwidth measurement, and an estimate of the correlation with a sinusoidal wave (leakage) were estimated for each episode. The fd was higher in induced episodes (4.75 ± 0.57 vs. 3.95 ± 0.59 Hz for the spontaneous episodes, P = 0.002), as well as the degree of organization assessed by the OI, bandwidth, and leakage parameters.

Conclusion: Clinical and induced VF episodes in humans have different spectral characteristics. Changes in the electrophysiological substrate or in the location of the arrhythmia wavefront at onset could play a role to explain the observed differences.

Key Words: Ventricular fibrillation, Spontaneous onset, Spectral analysis, Electrogram, Implantable cardioverter defibrillator

* Corresponding author: C/Periodista Antonio Herrero No. 25 B, Esc. 6, 3° M., 30007 Murcia, Spain. Tel: +34 968369211. Email: jjsanchezmunoz{at}gmail.com

Manuscript submitted 10 September 2008. Accepted after revision 2 December 2008.


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