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Europace 2009 11(2):245-251; doi:10.1093/europace/eun383
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

BASIC RESEARCH

Ventricular electrophysiology in congestive heart failure and its correlation with heart rate variability and baroreflex sensitivity: a canine model study

Shu-Xian Zhou*, Juan Lei, Chang Fang, Yu-Ling Zhang and Jing-Feng Wang

Division of Cardiology, Department of Internal Medicine, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, People's Republic of China

Aims: This study investigated ventricular electrophysiological characteristics and the correlation between these parameters and heart rate variability (HRV) and baroreflex sensitivity (BRS) in a canine congestive heart failure (CHF) model.

Methods and results: Haemodynamics, HRV, BRS, and ventricular electrophysiological variables were measured 4–5 weeks after sham operation (control dogs) and pacemaker implantation, and rapid right ventricular pacing at 240 bpm (CHF group). In the CHF group, significant differences from the control group in ventricular effective refractory period (VERP), monophasic action potential (MAP) duration (MAPD90), ventricular late repolarization duration (VLRD), the ratio of VERP to MAPD90, dispersion of ventricular recovery time (VRT-D), and ventricular fibrillation threshold (VFT) were noted. Both BRS and the time and power domain parameters of HRV were significantly decreased in the CHF group compared with the control group, and a significant, positive correlation between HRV and BRS was identified in the CHF group. Heart rate variability and BRS were negatively and significantly correlated with VLRD and VRT-D, and were positively correlated with VERP/MAPD90 and VFT in the CHF group.

Conclusion: These results suggest that ventricular electrophysiological characteristics correlated with abnormal autonomic nerve function may have important effects on sudden cardiac death. Further research is warranted.

Key Words: Congestive heart failure, Electrophysiology, Heart rate variability, Baroreflex sensitivity

* Corresponding author. Tel: +86 20 81332475, Fax: +86 20 81332360, Email: zzhoushuxian{at}yahoo.com.cn

Manuscript submitted 7 July 2008. Accepted after revision 15 December 2008.


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