© 1999 by European Society of Cardiology
First worldwide clinical experience with a new dual chamber implantable cardioverter defibrillator
Advantages and complications
Department of Cardiology, J.W. Goethe University Frankfurt, Germany; *Department of Cardiology, Georg-August University Göttingen, Germany
AIMS: The need for physiological pacing and for improving the ability to discriminate atrial from ventricular tachy-arrhythmias has prompted the development of dual chamber implantable cardioverter/defibrillators (ICDs).
METHODS: Fifty-two patients were implanted with a newly developed dual-chamber ICD providing rate-responsive physiological pacing (Ventak AV II DR). The device possesses two new arrhythmia detection algorithms (‘atrial fibrillation rate threshold’ and ‘ventricular to atrial rate relationship’) in addition to commonly used features such as ‘onset’ and ‘stability’. During implantation, the atrial and ventricular lead impedances and pacing thresholds were determined together with the defibrillation threshold. Prior to discharge, attempts were made to induce both atrial and ventricular tachyarrhythmias in order to test those new detection criteria. All patients were followed for at least 3 months.
RESULTS: The device was successfully implanted in all 52 patients. Placement of the atrial lead was successful in 50/52 patients (96%; P-wave 3·2±1·4 mV; impedance 576±123 |gQ; atrial pacing threshold 1·2±0·9 V). Prior to discharge, 32 episodes of atrial fibrillation (AF) alone, 38 episodes of AF with ventricular fibrillation and 10 episodes of AF with monomorphic ventricular tachycardia were induced in 33/50 patients (66%) and all were appropriately classified by the detection algorithm. During the 3 months follow-up, 12 patients (23%) had appropriate and successful therapies for ventricular arrhythmias, while four patients (8%) experienced inappropriate ICD therapies. Although all these episodes were detected correctly as supraventricular arrhythmias by the device, therapy was delivered because of incorrect or incomplete programming. In all cases reprogramming of the device resolved the problem.
CONCLUSION: Implantation of dual chamber ICDs is feasible and appears to improve discrimination of supraventricular from ventricular tachyarrhythmias. In addition, patients with tachyarrhythmias and concomitant bradyarrhythmias may benefit from simultaneous physiological pacing. However, implantation and follow-up of such patients should be performed at experienced centres since both surgical handling and programming of these devices is more difficult and complex than conventional ICDs.
Key Words: Implantable cardioverter/defibrillator, sudden cardiac death, dual chamber pacing, atrial fibrillation, discrimination of atrial and ventricular arrhythmias, inappropriate ICD shock
Correspondence: Stefan H. Hohnloser, MD, FACC, FESC, J.W. Goethe University, Department of Internal Medicine, Division of Cardiology, Theodor-Stern-Kai 7, D-60596 Frankfurt, Germany.
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